Specimen types & characterization: tuberculosis

Specimen types & characterization: tuberculosis

 

Specimen type Characterization Volume Origin
Sputum  Smear+/– Culture+/– 0.5 mL Africa, Latin America, South-East Asia
Serum  Smear+/– Culture+/– 0.5 mL Africa, Latin America, South-East Asia
Plasma EDTA  Smear+/– Culture+/– 0.5 mL Africa, Latin America, South-East Asia
Plasma P800  Smear+/– Culture+/– 0.5 mL Africa, Latin America, South-East Asia
Urine  Smear+/– Culture+/– 3.5 mL Africa, Latin America, South-East Asia
Saliva  Smear+/– Culture+/– 0.5 mL Africa, Latin America, South-East Asia
PAXgene tubes Smear+/– Culture+/– 2.5 mL Africa, Latin America, South-East Asia
Culture isolates MDR/XDR (from Smear+ Culture+ specimens) 1.0 mL Africa, Latin America, South-East Asia

Participant categories currently available include:

  • S+C+: Smear positive (any smear ZN or FM pos), culture positive (any culture pos) and MTB-complex (at enrolment)
  • S–C+: Smear negative (all smear neg/NA), culture positive (any culture pos) and MTB-complex (at enrolment)
  • Clinical TB CXR+: Smear negative, culture negative participants put on TB treatment based on clinical grounds (positive chest X-ray)
  • Likely subclinical TB: Smear negative, culture negative at baseline, culture positive at follow-up
  • Non-TB: Smear negative, culture negative participants that were not put on TB treatment at enrolment, and culture negative/NA and symptoms completely recovered/improved at follow-up
  • Non-Latent TB: same as the non-TB category but also includes available, negative Quantiferon test results
  • Latent TB: same as the non-TB category but also includes available, positive Quantiferon test results

 

Request specimens

 

Virtual Strain Bank

FIND also manages the Virtual Strain Bank (VSB), a freely available, online database that provides an overview of globally accessible TB strains. The VSB contains the relevant meta-data for over 400 of the ~800 strains available in the FIND Specimen Bank. It is easily searchable, and strains can be filtered and selected based on criteria such as country, clade, drug resistance, drug sensitivity, mutations and sequencing data availability.


Quick links

x